FOXO4-DRI / FOXO4 - 10mg

Peptide Name

FOXO4-DRI (Forkhead Box O4 D-Retro-Inverso Peptide)

Chemical Name/Structure

• Chemical Name: D-leucyl-D-threonyl-D-leucyl-D-arginyl-D-lysyl-D-alpha-glutamyl-D-prolyl-D-alanyl-D-seryl-D-alpha-glutamyl-D-isoleucyl-D-alanyl-D-glutaminyl-D-seryl-D-isoleucyl-D-leucyl-D-alpha-glutamyl-D-alanyl-D-tyrosyl-D-seryl-D-glutaminyl-D-asparagyl-glycyl-D-tryptophyl-D-alanyl-D-asparagyl-D-arginyl-D-arginyl-D-seryl-glycyl-glycyl-D-lysyl-D-arginyl-D-prolyl-D-prolyl-D-prolyl-D-arginyl-D-arginyl-D-arginyl-D-glutaminyl-D-arginyl-D-arginyl-D-lysyl-D-lysyl-D-arginyl-glycine

• Amino Acid Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-Gly-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-Gly-OH

• Molecular Formula: C_{228H_{388N_{86O_{64

• Molecular Weight: 5358.05 g/mol

CAS Number

• CAS Registry Number: 246055-10-9

Research Areas of Focus

Researchers are actively investigating FOXO4-DRI across several key cellular and systemic domains, including:

• Targeted Senescence and Selective Apoptosis: Investigating the peptide's ability to disrupt the binding interaction between FOXO4 and p53, thereby inducing nuclear exclusion of p53 and triggering mitochondrial-mediated cell death specifically in senescent cells.

• Tissue Regeneration and Anti-Aging Diagnostics: Assessing its capacity to eliminate accumulated "zombie" cells in living tissues, theoretically improving tissue microenvironments, restoring organ function, and reversing cellular aging markers.

• Musculoskeletal Preservation and Frailty: Exploring how the depletion of senescent cell populations influences overall physical performance, neuromuscular health, and age-related physical decline in in vivo models.

• Leydig Cell Function and Endocrine Support: Evaluating the peptide's role in alleviating age-related testosterone secretion insufficiency by selectively targeting senescent endocrine cells in testicular microenvironments.

• Chemotherapeutic Adjunct and Cellular Tolerance: Studying its potential to synergize with or enhance the efficacy of standard clinical interventions by selectively removing therapy-induced senescent cells from surrounding healthy tissues.

RESEARCH-USE NOTICE

This product is supplied by Biolabs for laboratory and research purposes only. It is not intended to diagnose, treat, cure, or prevent any medical condition and should not be used as a substitute for professional medical advice or treatment.

Any information provided is for general research, product identification, storage, and handling purposes only. The purchaser is responsible for using and storing the product appropriately and in accordance with applicable regulations.

Shipping & Stability Notice

Because our lyophilized (freeze-dried) vials are in a highly stable, solid-powder state, they are robust enough to withstand fluctuating temperatures during transit. Unlike liquid formulations, lyophilized FOXO4-DRI can safely be shipped under standard shipping conditions without compromising product integrity. If you reside in a regional or remote area where overnight delivery is not guaranteed, we strongly recommend choosing these lyophilized vials to ensure your research materials arrive in perfect condition.

Product Storage & Shelf-Life

At BioLabs, we source and synthesize only the highest-purity compounds to guarantee reliable experimental results. In its lyophilized powder form, FOXO4-DRI is exceptionally stable. Once received, the vials should be stored in a freezer at -20°C for long-term preservation (up to 3 years) or refrigerated at 2°C to 8°C if they are to be reconstituted and used in active research protocols within 12 months.