NAD+ 500 & 1000mg

Peptide Name

NAD+ (Nicotinamide Adenine Dinucleotide)

Chemical Name/Structure

• Chemical Name: Adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-\beta-D-ribofuranosylpyridinium, inner salt

• Molecular Formula: $\text{C}_{21}\text{H}_{27}\text{N}_{7}\text{O}_{14}\text{P}_{2}$

• Structure: Consists of two nucleotides (adenine and nicotinamide) joined through their phosphate groups.

CAS Number

53-84-9

Core Areas of Research Investigation

• Cellular Bioenergetics & Mitochondrial Function: Investigating the coenzymatic role of NAD+ in glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation as a primary electron carrier.

• Sirtuin Activation & Epigenetic Regulation: Exploring how cellular NAD+ availability modulates NAD+-dependent deacetylases (Sirtuins, primarily SIRT1 and SIRT3) to regulate mitochondrial biogenesis, gene silencing, and cellular stress responses.

• DNA Repair Mechanisms: Assessing the utilization of NAD+ as an obligate substrate by Poly(ADP-ribose) Polymerases (PARPs) to facilitate cellular DNA damage detection and repair cascades.

• NAD+ Consuming Pathways & Aging Models: Studying the enzymatic activity of CD38 and other glycohydrolases in degrading NAD+, and analyzing how systemic decline impacts cellular senescence.

• Calcium Signaling: Investigating the precursor role of NAD+ in generating cyclic ADP-ribose (cADPR), an intracellular calcium-mobilizing messenger.

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